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2025-11-05
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Articles
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##submission.howToCite##
ADRENERGIC AND CALCIUM REGULATION OF CONTRACTILITY OF NEONATAL RAT CARDIOMYOCYTES IN CULTURE
Maksimcheva Galina
Institute of Biophysics and Biochemistry
Tsiferova Nargiza
Institute of Biophysics and Biochemistry
Sabirov Ravshan
Institute of Biophysics and Biochemistry
##semicolon## neonatal cardiomyocytes, L-type calcium channels, verapamil, nifedipine, β₁-adrenoreceptors, isoproterenol, bisoprolol.
सार
The study demonstrated that activation of the adrenergic system leads to an increase in the frequency of contractions due to stimulation of bisoprolol-sensitive β₁-adrenoreceptors. In addition, neonatal cardiomyocytes demonstrated differential response to the calcium channel antagonist’s verapamil and nifedipine.
##submission.citations##
1. Deng YL, Zhao JY, Yao JH, Tang Q, Zhang L, Zhou HL, Zhang CT, Lv JG, Quan XQ. Verapamil suppresses cardiac alternans and ventricular arrhythmias in acute myocardial ischemia via ryanodine receptor inhibition. Am J Transl Res. 2017 Jun 15;9(6):2712-2722. PMID: 28670363; PMCID: PMC5489875.
2. Lang J., Timour Q., Lancon J.P., Aupetit J.F., Faucon G. (1988) Biphasic dose-response relationship observed with Bay k 8644 on atrioventricular nodal conduction inhibited by verapamil. Naunyn Schmiedebergs Arch Pharmacol 338(2): 196-201. DOI: 10.1007/BF00174870
