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ZENODO
Published
2026-01-08
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Articles
How to Cite
How to Cite
STUDY OF THE INFLUENCE OF A TETRAHYDROISOQUINOLINE BROMINE DERIVATIVEON FREE RADICAL OXIDATIVE PROCESSES
Umarova M.R
S.Y. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, 100170, Tashkent, Uzbekistan.
Terenteva E.O
S.Y. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, 100170, Tashkent, Uzbekistan.
AzimovaSh.S
S.Y. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, 100170, Tashkent, Uzbekistan.
Keywords: tetrahydroisoquinoline derivative; T-lymphoblastic leukemia; CCRF-CEM cells; cytotoxicity; lipid peroxidation; oxidative stress.
Abstract
The development of novel antileukemic agents requires not only high cytotoxic efficacy but also a clear understanding of their underlying mechanisms of action. Oxidative stress–mediated pathways are frequently implicated in cancer cell death; however, alternative mechanisms may offer therapeutic advantages [1].
References
1.Omotayo O, Siti A, and Mohd S. Evidence in Support of Potential Applications of Lipid Peroxidation Products in Cancer Treatment // Oxidative Medicine and Cellular Longevity, Volume 2013, Article ID 931251, 8 pages
2.Yasuyuki S, Takahiro S, Yoshio T Mechanism of the increase in lipid peroxide induced by cisplatin in the kidneys of rats // Toxicology Letters,Volume 62, Issues 2–3,1992,P. 293-300.
